Ukufundisisa okunokubakho okunokubakho:

Kutshanje, i-jama ngo-oncology (ukuba i-33.012) ipapashe isiphumo sophando obalulekileyo [1] liqela lesifo se-shai so jia-jia-jiaring kwisikolo se-sudring kunye ne-III yeNkulumbuso I-Tumor DNA methyItration kunye nokuNgeniswa komngcipheko) ". Esi sifundo sisifundo sokuqala seMbali yeLizwe ukuba sisebenzise itekhnoloji yeTekhnoloji ye-CTDNA ye-MRD yoMhlaza okhoyo, ekulindeleke ukuba iphucule itekhnoloji yeKlinikhi yeKlinikhi ye-MRD, kunye nokubeka iliso, kunye nokuphucula umgangatho ukusinda kwesigulana kunye nobomi bobomi. Isifundo sasivavanywa kakhulu yijenali kunye nabahleli, kwaye sadweliswa njengephepha eliphambili kule mbambano, unjingalwazi uJuan Ruiz-bañow ovela eUnited States wamenyelwa ukuba ahlole. Olu phononongo lwaluchazwa nguGenomeweb, amajelo eendaba ezikhokelayo ezikhokelayo eUnited States.

Umhlaza we-coloreval (CRC) sisisu esibuhlungu esiqhelekileyo se-gestrointenal iphecana eTshayina. I-2020 ye-Arhente yamazwe aphesheya yophando ngomhlaza (i-Iarc) Idatha ibonisa ukuba amatyala amatsha angama-555 000 kwi-akhawunti ye-China malunga ne-1/3 yehlabathi, kunye nenqanaba lezemigangatho lokuphuma kwi-China eChina eChina eChina; I-286,000 ye-Akhawunti ye-Akhawunti ye-1/3 yeHlabathi, iBiniking njengesihlanu eyona nto ixhaphakileyo yokusweleka komhlaza eTshayina. Isihlanu sonobangela we-china. Kuyaphawuleka ukuba phakathi kwabaguli abafunyanisiweyo, amabali e-TNM I, II, i-IV i-18.6%, i-42%, i-42.7% ne-8.2% ngokwahlukeneyo. Ngaphezulu kwe-80% yezigulana zikwinqanaba eliphakathi kunye namashumi amahlanu, kunye ne-44% yazo ngaxeshanye okanye i-tenterochtrodenist ezikude okanye zisengozini yempilo yethu kwaye zibangela umthwalo omkhulu wentlalo kunye nezoqoqosho. Ngokweenkcukacha zeZiko leDlawule lomhlaza leSizwe, ukunyuka komgangatho wonyaka kwiindleko zonyango lwe-cologetal e-China limalunga ne-6.9% ukuya kwi-9.2% ukuya kwi-9.2%, kunye nenkcitho yempilo yezigulo inokuthatha i-60% yengeniso yosapho. Izigulana zomhlaza zinesifo kwaye kwaye ziphantsi koxinzelelo olukhulu kwezoqoqosho [2].
Iipesenti ezingamashumi asithoba ze-colocre schools zinokususwa ngokuqinileyo, kwaye kwangoko ithumba ifunyenwe, ukuphakanyiswa kwenqanaba leminyaka emihlanu emva kokuphangwa kweminyaka emihlanu, kodwa iqondo lokuphinda liphucule i-reactores malunga ne-30%. Ireyithi yeminyaka emihlanu yomhlaza we-cologetal kumazwe angama-90,0, i-78.6%, i-53.8% kunye ne-10.4% ye-I, ngokulandelelana.
Isifo esincinci esincinci (i-Mrd) sisizathu esikhulu sokuphindaphinda emva kokuphathwa kwe-gourical. Kwiminyaka yakutshanje, itekhnoloji yokuchonga i-MRD ye-sumords eqinileyo iphumelele ngokukhawuleza, kwaye izifundo ezininzi ezibonakalayo ziqinisekisile ukuba imeko ye-MRD ye-PRD inokubonisa umngcipheko wokuphinda umhlaza webala. Uvavanyo lwe-CTDNA luneengenelo zokuba azinantsingiselo, ezilula, ezikhawulezayo, ezinofikelelo oluphezulu kunye nokufikelela kwi-heterogeneity.
Izikhokelo ze-US NCCN zeColon Clon kunye nezikhokelo zeCSCO zeCSCO zomhlaza weColoreal State (uvavanyo lwe-CTDIN unokubonelela ngolwazi lokufumana umngcipheko kwi-Colony kwiPormatic Consures kwiNqanaba le-II okanye i-III Clon Dean umhlaza. Nangona kunjalo, ukugxila okukhoyo kwizifundo kwi-CTDN Sheet esekwe kwiTekhnoloji yeTekhnoloji ephezulu, i-NGS), enexesha elide, kunye nokungabikho kokungaphantsi komhlaba kwizigulana zomhlaza.
Kwimeko yenqanaba le-COORTEATAL CLOORTAL abaguli abagulayo, i-NGS-I-NGS-isekwe kwiindleko zokuhlola ii-dolomatic ukuya kuthi ga kwi-10,000 yeedola kutyelelo olunye kwaye ifuna ixesha lokulinda ukuya kwiiveki ezimbini. Ngovavanyo lwe-Mundenity lokuvavanywa kolu phononongo, uColonaiq ®, abaguli banokuba nembeko ye-CTDNA ye-CYDNA kwisishumi sexabiso kwaye bafumana ingxelo encinci kangangeentsuku ezimbini.
Ngokwe-560,000 yamatyala amatsha omhlaza we-coloretal e-China nyaka ngamnye, izigulana zeklinikhi ikakhulu zinesigaba sokubeka iliso kwi-SPHINAMIC
Ingabonwa ukuba iziphumo zophando zinenzululwazi ebalulekileyo kunye nokubaluleka okusebenzayo. Ngokusebenzisa izifundo ezikhulu zeklinikhi, iqinisekisile ukuba i-PFR-Isekelweni leTekhnoloji ye-Multiene Methyne Methyne Inokusetyenziselwa ukuqaliswa kwe-colorection kunye nokusebenza kwexesha kunye nokusebenza kwexabiso, ukusebenza kakuhle ukuze kuxhamle abaguli bomhlaza abaninzi. Olu phononongo lusekwe kwiColonaiq ®, uvavanyo lwe-gene-Gee-Gee-Gee-Gee-Geerement umhlaza we-coloretal ophuhliswe nguBuney, ixabiso lakhe lesicelo kwi-Cloubling yokuqala kunye nokuxilongwa kwangoko kuqinisekisiwe sisifundo sekliniki esembindini.
I-Gastroenterology (ukuba33.88), ijenali ephezulu yehlabathi kwicandelo le-gestustini yesibhengezo se-Zhongshan, ekwakhethileyo ukusebenza kweYunivesithi yaseFudan kunye namanye amaziko asemthethweni e-fudan kunye nokuxilongwa kwangoko Umhlaza we-coloretal, kwaye ekuqaleni wakhangela ikwaphonononge isicelo esinokubakho kwi-progeno yesifo sokwenza umhlaza wamabala.

Ukuqinisekisa ngakumbi ukusetyenziswa kweklinikhi ye-CTDNA METYIRT kwi-Serferation, iNkokeli yoNyango ye-I-III iqokelele i-I-CORTERORY STERORY ASTERRY STERORY ASTERRY STERRY STERRY STERRY STERRY Ukuvavanywa kwegazi le-CTDINC.
Okokuqala, kwafunyaniswa ukuba uvavanyo lwe-CTDNA lwaluqikelela umngcipheko wokuphinda-phinda abaguli bemihlatha kwangoko, bobabini bakuqala kunye nendawo yokuqala. Abaguli abasebenza kakuhle be-CTDna abane-CTDna babenokwenzeka ukuba baphinde kwendawo yokuphinda-phinda kwe-CTDna-APROOPE (22.0%> 4.7%). Uvavanyo lwe-CTDNATNAPE LE-CARTAPECATIONAPE lusaxelwe kwangaphambili: inyanga enye emva kokufika kwengqondo, izigulana ezinezona zilungileyo ze-CTDna zinokwenzeka kangako kubantu abangalunganga; Eli qela lafumanisa ukuba i-CTDNA edityanisiweyo kunye ne-CEA ihlole ukusebenza ngokuphuculweyo okufumanayo (AUC = 0.843), kodwa umahluko wawungakhange ubonakale wedwa u-CTDNA wedwa (AUC = 0.839).
Isimo seklinikhi sidityaniswe nezinto ezinomngcipheko okwangoku zisisiseko sokwenza umngcipheko kwizigulana zomhlaza, kunye nenani elikhulu lezigulo ezingcono, kwaye kukho imfuneko engxamisekileyo yokufumana unyango kunye nonyango. Ngokusekwe koku, iqela labaguli abaqeqeshiweyo ngamanqanaba e-CORTERATAL KWI-RUGRE YOVAVANYO OLUFANELEKILEYO KWI-CORTE YOVAVANYO OLUFANELEKILEYO (I-T8)) kunye nexesha lokunyanga ama-3/6). Uhlalutyo ufumanise ukuba izigulana ezisengozini enkulu yezigulana ze-CTDna zinezinga elisezantsi ukuba zifumene iinyanga ezintandathu unyango; Kwiqela lemingcipheko eliphantsi labaguli abane-CTDna abalungileyo, kwakungekho mahluko ubambi phakathi komjikelo wokunxibelelana nonyango kunye nezigulana; Ngelixa izigulana ezingalunganga ze-CTDna zazinentsingiselo engcono kakhulu kunezigulana ezine ezilungileyo kunye nexesha elide lokuphinda " Inqanaba I kunye nenqanaba lomngcipheko ophantsi II Colorer Umhlaza womhlaza we-CTDna-ongenayo ukuba ungaphindaphinde kwiminyaka emibini; Ke ngoko, ukudityaniswa kwe-CTDN enezinto zeklinikhi kulindeleke ukuba kuqhubekeke kongezeleleko lomngcipheko kunye nokuqikelela okungcono ukuphindaphinda.

Umzobo 1. Uhlalutyo lwePlasma CTDNA kwi-POM1 yokufunyanwa kwangoko komhlaza we-cologetal
Iziphumo ezizezinye ze-CTDna zibonisa ukuba umngcipheko wokuphinda ubekhona wawuphakamisa abaguli be-CTDNATNATALY Sydna yovavanyo lwe-CTDNALSE), kwaye ukuba i-CTDNAYICHINO YOKUGQIBELA IXESHA LOKUGQIBELA Ukuphinda ungenelelo kunye nongenelelo ngexesha elifanelekileyo.

Umzobo 2. Uhlalutyo lwe-CTDna ngokusekwe kwi-deditudinal cohort yokufumana i-coloct yomhlaza wokuphinda ubhatale

"Inani elikhulu lezifundo zamayeza eThenteli kwi-Colorement Cancer ikhokela uqeqesho, ngakumbi uvavanyo lwe-MRD olusekwe kwi-CTDna lubonisa ukuba izigulana ezinemifanekiso ye-COARTAL ngokunika amandla umngcipheko wokuphinda ubeke phantsi.

Inzuzo yokukhetha i-DNA METHY Ukumakisha i-Novel MRD malunga nokufunyanwa kwe-Novel, kukuba ayifuni ukuba iziphumo ze-genomes, zithintela iziphumo ezinobuxoki, i-enay izifo eziqhelekileyo ezivela kwizicubu eziqhelekileyo.
Olu phononongo kunye nezinye izifundo ezinxulumene noko ziqinisekisa ukuba uvavanyo lwe-MRD lwe-CTDna luyeyona nto ibaluleke kakhulu yomhlaza we-I-III uphondo lwe-I-III.
Intsimi ye-MRD iguqukele ngokukhawuleza nenani lezinto ezinobuchule, ezibuthathaka nezithobileyo ezisekwe kwi-epigenetics (i-DNA Methyting kunye ne-fragmentics) kunye ne-gemine-genologing). Silindele ukuba i-Colonaiq ® iyaqhubeka nokulungelelanisa izifundo zeklinikhi enkulu kwaye zinokuba sisibonisi esitsha sovavanyo lweMRD esidibanisa ukufikeleleka, ukusebenza okuphezulu kunye nokufikeleleka kwaye kungasetyenziswa ngokubanzi kwinkqubo yekliniki eqhelekileyo. "
Izalathiso
[1] Molo, ewe, Han l, Zing hl, u-dai w, xum, xum, nung w, nung,, nung w, nung w, nung w, the the matthyred. UJama Outo. 2023 APR 20.
[2] "Umthwalo wesifo somhlaza esihlambulukileyo kubahlali baseTshayina: Ngaba itshintshile kwiminyaka yakutshanje? , Ijenali yaseTshayina yesipikudemiology, Vol. 41, No. 10, Oktobha 2020.
. Ukucetyiswa okujolise kokulandela okulandelayo kokujikeleza kwe-DNA ye-DNA yokulandelela isifo esincinci esiyintsalela kwi-Colon yeKolon. Ann Oncol. Nov 1, 2019; 30 (11): 1804-1812.
. Umhlaza uphakamise i-MVUM. 2019; 75: 1-11.