Yimalini ityhefu ye-oicron inqabile? Izifundo ezininzi ze-Intanethi zibonisa

"Ingcazela ye-omicron isondele kweyesikhuhla samaxesha onyaka" kunye "ne-omicron incinci kakhulu i-pathogenic kuneDelta". ...... kutshanje, iindaba ezininzi malunga nelilofileyo lesithsaba esitsha esitshatileyo se-omin osasazeke kwi-Intanethi.

Ewe, ukusukela ekuvelisweni kwe-Omicron iguquka ngoNovemba 2021 kunye nokuxhaphaka kwehlabathi, uphando kunye nengxoxo ngolwimi kunye nosulelo luye lwaqhubeka lukhona. Ithini iprofayile ye-Omiclance yangoku? Luthetha ntoni uphando malunga nalo?

Izifundo ezahlukeneyo zelebhu: I-Omipharon ayinanjana
Ngapha koko, ekuqaleni kukaJanuwari 2022, isifundo kwiDyunivesithi yaseHong Kong Lia Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Ka Kakho faculty of Stothogelty onokuthi ufakelwe uxinzelelo lwantlandlolo.
Kwafunyaniswa ukuba i-Omictron Retronunt Suren yayingasebenzi ekusebenziseni i-Transmenzerrane ye-prosese (i-TMPRS2), ngelixa i-RMPRS2 inokuqhuba i-vills2 ye-villavirsus entsha. Kwangelo xesha, abaphandi baphawula ukuba ukuphindaphinda i-Omictron Incitshisiwe kakhulu kwiseli yabantu iCalu3 kunye ne-caco2.

I-Intanethi yemifanekiso

In the k18-hACE2 mouse model, Omicron replication was reduced in both the upper and lower respiratory tracts of mice compared to the original strain and the Delta mutant, and its pulmonary pathology was less severe, while Omicron infection caused less weight loss and mortality than the original strain and the Alpha, Beta and Delta mutants.
Ke ngoko, abaphandi bagqiba kwelokuba ukuphindaphinda i-omicron kunye ne-pathojinity zancitshiswa kweempuku.

I-Intanethi yemifanekiso

Ngomhla we-16 Meyi 2022, indalo yapapashwa iphepha nguYoshihiro Kawaoka, i-virogist ekhokelayo kwiDyunivesithi yaseGoldonin, eqinisekisa okwesilwanyana e-Omilron Ba. nge-vin engaphantsi koxinzelelo lwangaphambili.

Abaphandi bakhetha i-Ba.2 Iintsholongwane ezodwa eJapan ziye zosulela iimpuku ze-K18-hace2 kunye ne-hamsters zisezantsi zentsholongwane kwi-vissin kunye nempumlo yosulelo lwesithsaba (P <0.0001).

Esi siphumo segolide segolide siqinisekisa ukuba i-omicron iphosakele ngaphantsi kohlobo lwasendle. Ngokwahlukileyo, kwakungekho mahluko ubalulekileyo kwizixhobo zentsholongwane kwimiphunga kunye neempumlo zeemodeli zezilwanyana ezilandela i-ba.2 kunye nosulelo.

I-Intanethi yemifanekiso

I-PCR ye-vcrul i-viral Asses ibonise ukuba zombini i-BA..2 kunye ne-Bice yosulelo zinemithwalo yentsholongwane kwimiphunga kunye neempumlo zinemiphunga entsha, ngakumbi kwimiphunga (P <0.0001).

Ifana neziphumo kwiimpuku, izininzi zentsholongwane ezifunyenwe empumlweni kunye nemiphunga ye-BA..2 I-Hamsters esulelekileyo yayingaphantsi kwentsholongwane, ngakumbi, isiqingatha se-hamsters esosulelekileyo asikhuli.

Kwakuyifumana kwakhona ukuba imizi yentsusa, i-ba.2 kunye ne-BA.1 ye-Se.1 Ukungathathi cala kwe-sera kulungelelwaniso kuhambelana nezinto eziguqukayo zehlabathi xa zikhe zalungiswa.

I-Intanethi yemifanekiso

Idatha yeHlabathi yeHlabathi: I-Omicron inokwenzeka ukuba ibangele ukugula kakhulu

Iqela lezifundo ezingentla zichazile ukuncitshiswa kokuncitshiswa kwe-omitron kwiimodeli zezilwanyana, kodwa kuyafana nehlabathi lokwenyani?

Ngomhla we-7 kaJuni 2022, owapapasha ingxelo evavanya umahluko kubuqili babantu abosulelwe ngexesha le-omicron (B.1.1.529) ekuthethelelwa kobhubhane.

Le ngxelo ibandakanya i-16,749 i-inplaries entsha yeHoronary elivela kuwo onke amaphondo oMzantsi Afrika, kubandakanya i-16,749 ukusuka kwi-16,749 ukusuka kwi-Delta Epidemic (2021/29 ukuya kwi-2021/10) evela kwi-Omiphimimic (2021/2/20). Izigulana nazo zaye zahlulwa kakhulu, zinzulu kwaye zingenabunzulu.

Eyona nto ibaluleke kakhulu: Ukufumene umoya wokuhlaselwa, okanye ioksijini kunye neoksijini ye-exynasas ephezulu, okanye i-oxmnasal ye-oxrane yeoksithane (i-ECMO), okanye ukwamkelwa kwi-ICU ngexesha lokunyangwa.
-Enza (thambisa): ifumene ioksijini ngexesha lokuzala esibhedlele
-bukhali: Ukuba akukho nanye kwezi meko ingentla, isigulana asisinamandla.

Idatha ibonise ukuba kwiqela le-Delta, i-49.2% yayinzulu, i-7.7% yayibalulekile kwaye i-28% yazo zonke izigulana ezibhedlele esibhedlele zasweleka, i-28.1% yazo zonke izigulana ezosulelekileyo ze-Omicin of Sumin of Recin Office obolekileyo zafa. Kwakhona, ubude bokuhlala bekukho iintsuku ezisi-7 kwiqela le-Delta xa kuthelekiswa neentsuku ezi-6 kwiqela le-omictroni.

Ukongeza, ingxelo ihlalutye izinto eziphathwayo, isini, imeko yokugonya kunye neendlela zokugonya kwaye zigqibe kwelokuba i-omicron (B.1.41) idityaniswe ne-Oneron (B.1.41) kwaye i-0.45: 0.55; p <0.001).

I-Intanethi yemifanekiso

Kwizityholo ezahlukeneyo ze-omicron, ezinye izifundo zihlaziye imbiza yabo ngokweenkcukacha.

Isifundo se-cohort evela e-England ihlalutya ama-20770 amatyala ase-Delta, ama-52605 amatyala e-omicron b.1.1.529, kwaye afumanise ukuba i-Demin Bi.2% ye-Delta, i-0.5.5% ye-BA.2. Emva kokuhlengahlengiswa kwezinto ezibadala, esi sifundo sigqityiwe ukuba umngcipheko wokufa wawusezantsi kakhulu kwi-BA..

I-Intanethi yemifanekiso

Olunye ufundisiso oluvela kuMzantsi Afrika luvavanye umngcipheko wokulaliswa esibhedlele kunye nomngcipheko wesiphumo esinamandla seDelta, Ba.2 kunye ne-BA.4 / Ba.5 .5. Iziphumo zibonise ukuba kwezigulana ezingama-98,710 ezisandul 'ukusulelwa zibandakanyiwe kuhlalutyo, i-3825 (3.9%) zamkelwa esibhedlele, ezazingama-1276 (33.4%).

Phakathi kwabo bosulelwe yinguqulelo eyahlukileyo, i-57.7% yezigulana ezosulelekileyo zaphuhlisa isifo esiqatha (97/168), ithelekiswa nezigulana ezingama-990 (990/8) kunye ne-27,5% ye-BA.4 / 22/80 (22/80). Uhlalutyo oluqhelekileyo lubonise ukuba ithuba lokuphuhlisa isifo esinzulu phakathi kwezo usulelekileyo i-Delta> Ba.2, ngelixa i-Ba.5 ayifani kakhulu xa kuthelekiswa ne-ba.5.
Ukucuthwa kwenjineli, kodwa ukuphononongwa okufunekayo

Izifundo zelebhu kunye nedatha yokwenyani evela kumazwe aliqela ibonisile ukuba i-omicron kwaye amatywina ayo angaphantsi kwaye angaphantsi okunokubangela ukugula kakhulu kunolosulelo loqobo.

Nangona kunjalo, inqaku lokuphononongwa kweLancet kaJanuwari 2022 le-lancet, elinomxholo othi 'Maller' laliphawuleka ukuba nangona i-OICRORY 'iphawuleka ukuba i-Ofisi yeSibhedlele ibaluleke kakhulu kunokubangela ukuba izifo ezahlukeneyo zinokubakho. (Nangona kunjalo, kule Ngokubali yaBantu Abaselula Abaselula, i-21% yezigulana ezibhedlele echithwe yi-SARS-2 ye-Omicron eyahlukileyo ye-Ouimilical yeKlinikhi, i-ocuron eyahlukileyo ye-Ouemer kunye nenqanaba eliphantsi losulelo okanye ukugonya.)

Ekupheleni kwengxelo esele ikhankanyiweyo ngaphambili, iqela laphawula ukuba ngaphandle kokuncitshiswa kokuncitshiswa komthwalo wangaphambili, phantse izigulana ezitshatileyo ze-omicron (B.1.1.5) ziphuhlise izifo eziphakamileyo kunye nokusweleka kwabantu abadala okanye abangafakwanga abantu abalupheleyo. . i-subnimoints ebonakalayo kunye nokufa kwabantu.)

Idatha yangaphambili evela kwi-omitron xa ikhulisa amaza esihlanu eHong kaHong Kong wabonisa ukuba i-4 kaMeyi 202765 i-5920% yeTroude ye-5920% yangaphezulu kwe-2.720% ye-20015 ye-20030 yeminyaka engaphezulu kwe-59.30 yeli qela lalingapheli.

Ngokwahlukileyo, i-2% kuphela ye-zealands entsha ngaphezulu kweminyaka engama-60 ubudala ayifakwanga, ehambelana kakhulu nenqanaba lokufa eliphantsi le-0.07% kwi-crown entsha yesithsaba.

Kwelinye icala, ngelixa ihlala iphikisana ukuba iNewcastle inokuba sisifo esinexesha, isifo kwixesha elizayo, kukho iingcali zezifundo ezithatha umbono owahlukileyo.

Izazinzulu ezintathu kwiDyunivesithi yase-Oxford kunye neZiko loPhangiso lwe-Europe laseYurophu likholelwa ukuba ubukhali be-Omicron bunokuba yindalo nje, kwaye oko kwaqhubeka nokuzivelela okungekho mthethweni (i-Antigenic ye-Antigenic) inokuzisa izinto ezahlukeneyo.

Ngokungafaniyo nokukhula komzimba kunye nokuzinikezela, eziphantsi koxinzelelo oluqinileyo lwendaleko, ivila lihlala liyinto nje ebonakalayo 'yemveliso' yendaleko. Iintsholongwane ziyavela ukukhulisa amandla abo okusasazeka, kwaye oku kunokukhokelela ekunyukeni koluvisayo. Umzekelo, ngokwandisa umthwalo wentsholongwane ukuqhuba udluliselo, lusenokubangela izifo eziqatha.

Ayisiyiyo kuphela loo nto, kodwa i-veleary iya kubangela ukwenzakala okunqongopheleyo ngexesha lokusasazeka kwentsholongwane ukuba iintsholongwane zivela ikakhulu kwintsholongwane, zinexesha elininzi lokusasaza ngaphambi kokuba zibangele imiphumo emibi.

I-Intanethi yemifanekiso

Kwiimeko ezinjalo, kunokuba nzima ukuqikelela umkhwa we-crown entsha yoxinzelelo lwe-omin, kodwa iindaba ezilungileyo zezokuba isitayile esincinci se-crown sibonakalise indlela ebalulekileyo yokulwa lobhubhasi ngeli nqanaba.
IMIQATHANGO: Eli nqaku laqwalaselwa ngokucokisekileyo nguPapan Zhou, i-PhD, iSikolo seYunivesithi yasePinghl kunye ne-Poulldourral, i-USA IZiko loPhando, i-USA
Ukuzivavanya kwe-omicron antign regent ekhaya