Abona bantu baphezulu abalishumi bezeNdalo kwiNzululwazi:

IYunlong Cao yeYunivesithi yasePeking ibizwa ngokuba kuphando olutsha lwe-coronavirus

Nge-15 kaDisemba 2022, iNdalo yabhengeza i-Nature's 10 yayo, uluhlu lwabantu abalishumi abebeyinxalenye yeziganeko ezinkulu zenzululwazi zonyaka, kwaye amabali abo anika imbono eyodwa kwezinye zeziganeko zenzululwazi ezibalulekileyo kulo nyaka ungaqhelekanga.

Kunyaka weentlekele kunye nezinto eziye zafunyaniswa zinika umdla, iNdalo yakhetha abantu abalishumi kwizazi ngeenkwenkwezi eziye zasinceda ukuba siqonde eyona ndawo ikude kakhulu kwindalo iphela, kubaphandi abaye baba negalelo kubhubhani weNqaku eNtsha kunye nemonkeypox, koogqirha botyando abathe baqhawula imida yokufakelwa kwamalungu. , utsho u-Rich Monastersky, umhleli oyintloko weeMpawu zeNdalo.

UYunlong Cao uvela kwiziko le-Biomedical Frontier Innovation Centre (BIOPIC) kwiYunivesithi yasePeking. UGqr. Cao uphumelele kwiYunivesithi yaseZhejiang nge-Bachelor's degree kwi-Physics waza wafumana i-PhD yakhe kwiSebe leKhemistri kunye neKhemikhali ye-Chemistry yeYunivesithi yaseHarvard phantsi kwe-Xiaoliang Xie, kwaye ngoku unguMdibaniso woPhando kwi-Biomedical Frontier Innovation Centre kwiYunivesithi yasePeking. UYunlong Cao ebegxile kuphuhliso lwetekhnoloji yokulandelelana kweseli enye, kwaye uphando lwakhe luye lwanceda ukulandelela ukuvela kwee-coronavirus ezintsha kunye nokuxela kwangaphambili ezinye zeenguqu ezikhokelela ekudalweni kohlobo olutsha lwe-mutant.

Nge-18 kaMeyi 2020, uXiaoliang Xie/Yunlong Cao et al. yapapasha iphepha kwijenali yeCell enesihloko esithi: “Izilwa-buhlungu ezinamandla zokungathinteli ngokuchasene ne-SARS-CoV-2 ezichongwe ngolandelelwano lweseli enye yeeseli ze-B zesigulana ezipholayo” Iphepha lophando.

Olu phononongo lunika ingxelo yeziphumo ze-coronavirus entsha (i-SARS-CoV-2) yokungathathi hlangothi kwesikrini se-antibody, esasebenzisa i-RNA eneseli enye kunye neqonga le-VDJ lokulandelanisa ukuchonga i-14 ye-anti-monoclonal antibodies evela kwi-antigen-bound IgG1 engaphezulu kwe-8500. Ngama-60 abaguli abafumene i-COVID-19.

Olu phononongo lubonisa okokuqala ukuba ulandelelwano oluphezulu lweseli enye lunokusetyenziswa ngokuthe ngqo ekubhaqweni kweziyobisi kwaye lunoncedo lokuba yinkqubo ekhawulezayo nesebenzayo, ethembisa ukuyiguqula indlela abantu abajonga ngayo ukuthomalalisa amajoni omzimba kwiintsholongwane ezosulelayo.

Nge-17 Juni 2022, Xiaoliang Xie/Yunlong Cao et al. yapapasha iphepha elinesihloko esithi: BA.2.12.1, BA.4 kunye ne-BA.5 izilwa-buhlungu ezibangelwa sisifo se-Omicron kwijenali yeNdalo.

Olu pho nonongo lufumene ukuba i-subtypes entsha ye-Omicron ye-mutant i-BA.2.12.1, i-BA.4 kunye ne-BA.5 ibonise ukunyuka kwe-immune yokuphunyuka kunye nokungathathi hlangothi okubalulekileyo kwe-plasma yokuphunyuka kwi-Omicron BA.1 efunyenwe izigulane.

Ezi ziphumo zibonisa ukuba ugonyo lwe-Omicron olusekelwe kwi-BA.1 alusayi kufaneleka njenge-booster kwimeko yangoku yokugonywa kunye nokuba i-antibodies eyenziwayo ayiyi kubonelela ngokhuseleko olubanzi ngokuchasene noxinzelelo olutsha lwe-mutant. Ngaphaya koko, ukungakhuseleki komhlambi ngenxa yosulelo lwe-Omicron kunzima kakhulu ukufezekiswa ngenxa yento 'ye-immunogenic' yee-coronavirus ezintsha kunye nokuvela ngokukhawuleza kweendawo zokuguqula amajoni omzimba.

Nge-30 ka-Okthobha ka-2022, iqela lika-Xiaoliang Xie/Yunlong Cao lapapasha iphepha lophando elinesihloko esithi: Imprinted SARS-CoV-2 humoral immunity ibangela ukuguquka kwe-Omicron RBD kwi-preprint bioRxiv.

Olu pho nonongo lubonisa ukuba inzuzo ye-XBB ngaphezu kwe-BQ.1 ingaba ngenxa yenxalenye yeenguqu ezingaphandle kwe-domain binding domain (RBD) ye-spinosin, ukuba i-XBB ibuye ibe neenguqu kwiindawo ze-genome encoding i-N-terminal structural domain (NTD) ) ye-spinosin, kwaye ukuba i-XBB iyakwazi ukubaleka amajoni omzimba angathathi hlangothi ngokuchasene ne-NTD, enokuthi ivumele ukuba ichaphazele abantu abagonyelwe kwi-BQ.1 kunye nee-subtypes ezinxulumene nazo. Nangona kunjalo, kuyafaneleka ukuba uqaphele ukuba iinguqu kwingingqi ye-NTD zenzeka kwi-BQ.1 ngesantya esikhawulezayo. Olu tshintsho luphucula kakhulu ukukwazi kolu lwantlukwano ukubaleka izilwa-buhlungu eziveliswa lugonyo kunye nosulelo lwangaphambili.

UDkt. Yunlong Cao uthe kunokubakho ukukhuselwa kwi-XBB ukuba yosulelwe yi-BQ.1, kodwa uphando olongezelelweyo luyafuneka ukunika ubungqina boku.

Ukongeza kuYunlong Cao, abanye abantu ababini benze uluhlu ngegalelo labo elibalaseleyo kwimicimbi yezempilo yoluntu, uLisa McCorkell kunye noDimie Ogoina.

U-Lisa McCorkell ngumphandi one-Long COVID kwaye njengelungu eliseka i-Pandle-Led Research Collaborative, uye wanceda ukwazisa kunye nenkxaso-mali yophando ngesi sifo.

UDimie Ogoina ngugqirha wesifo esosulelayo kwiYunivesithi yaseNiger Delta eNigeria kwaye umsebenzi wakhe kwi-monkeypox ubhubhane eNigeria unikeze ulwazi olubalulekileyo ekulweni nobhubhane lwemonkeypox.

Ngomhla we-10 kuJanuwari ka-2022, iYunivesithi yaseMaryland School of Medicine yabhengeza ukufakelwa kwentliziyo yehagu yokuqala eyimpumelelo yehlabathi kumntu ophilayo, xa isigulana sentliziyo esineminyaka engama-57 ubudala uDavid Bennett safumana uqhaqho lofuzo lwentliziyo yehagu ukusindisa ubomi bakhe. .

Nangona lentliziyo yehagu ikhulise ubomi buka David Bennett ngeenyanga ezimbini kuphela, ibe yimpumelelo enkulu kunye nembali eyimpumelelo kwinkalo ye-xenotransplantation. U-Muhammad Mohiuddin, ugqirha wotyando okhokele iqela elagqibezela olu fakelo lwentliziyo yehagu ehlelwe ngokwemfuzo, ngokungathandabuzekiyo uthiwe thaca kuluhlu lweNdalo yaBantu abaPhezulu abali-10 boNyaka.

Abanye abaliqela bakhethelwa ukuqhubela phambili impumelelo yenzululwazi engaqhelekanga kunye nenkqubela phambili ebalulekileyo yomgaqo-nkqubo, kuquka isazi ngeenkwenkwezi uJane Rigby weZiko leNASA iGoddard Space Centre, owadlala indima ephambili kuthumo lweWebb Space Telescope lokungenisa iteleskopu emajukujukwini nokusebenza kakuhle, ethatha isakhono soluntu sokuphonononga. indalo ukuya kwinqanaba elitsha nelingaphezulu. u-alondra Nelson, njengoMlawuli obambeleyo woMgaqo-nkqubo weSayensi neTekhnoloji we-Ofisi yeSayensi neTekhnoloji, uncede ulawulo lukaMongameli Biden ukuphuhlisa izinto ezibalulekileyo ze-ajenda yesayensi, kubandakanya umgaqo-nkqubo wokuthembeka kwesayensi kunye nezikhokelo ezitsha kwisayensi evulekileyo. UDiana Greene Foster, umphandi wokuqhomfa kunye nedemographer kwiYunivesithi yaseCalifornia, eSan Francisco, unikezele ngedatha ephambili malunga nefuthe elilindelekileyo lesigqibo seNkundla ePhakamileyo yase-US sokurhoxisa ukhuseleko lomthetho lwamalungelo okuqhomfa.

Kukwakho namagama akuluhlu lwalo nyaka aphambili abalulekileyo kuphuhliso lokutshintsha kwemozulu kunye nezinye iingxaki zehlabathi. Zizo: U-António Guterres, uNobhala-Jikelele weZizwe eziManyeneyo, uSaleemul Huq, uMlawuli weZiko leZizwe ngeZizwe loTshintsho lweMozulu kunye noPhuhliso eDhaka, eBangladesh, kunye noSvitlana Krakovska, iNtloko yeqela lase-Ukraine kwiPhaneli yeZizwe eziManyeneyo malunga noTshintsho lweMozulu ( IPCC).