Iindaba - Umbulali ofihlakeleyo kwiCanine WorldMalignant Hyperthermia

Abanikazi bezilwanyana basenokuba bevile nge-canine malignant hyperthermia-isifo esibulalayo sofuzo esihlala sivela ngokukhawuleza emva kwe-anesthesia. Embindini wayo, inxulumene ngokusondeleyo nokungaqhelekanga kwiUhlobo lwe-RYR1, kwayeuvavanyo lwe-nucleic acidngundoqo ekuchongeni le ngozi yemfuza kwangaphambili.

Ngokuphathelele kwipatheni yayo yelifa, ukuvumelana kwezenzululwazi kukuba iyalandelailifa elilawulayo le-autosomal kunye nokungena okungaphelelanga-okuthetha ukuba izinja ezithwele imfuza eguqukileyo zisenokungasoloko zibonisa iimpawu; ukubonakaliswa kuxhomekeke kwizinto ezibangelayo zangaphandle kunye namanqanaba e-gene expression.

Namhlanje, makhe singene nzulu kwindlela esi sifo esenzeka ngayo phantsi kolu hlobo lofuzo kunye nokuba zeziphi na izinto ezibangela ukuba sibangele.

Imfihlakalo engasemva kwe-RYR1 Gene ephuma kuLawulo

Ukuqonda indlela ye-canine malignant hyperthermia, okokuqala kufuneka sazi "umsebenzi wosuku" we-RYR1 gene-usebenza njenge "umgcini wesango le-calcium channelsNgaphantsi kweemeko eziqhelekileyo, xa inja ishukuma okanye idinga ukunyanzeliswa kwemisipha, umjelo olawulwa yimfuza ye-RYR1 ivula, ikhuphe i-calcium ions egciniweyo kwi-fibers ye-muscle ukuze iqalise ukuchithwa.

yonke inkqubo ihlala icwangcisiwe kwaye ilawulwa, ngaphandle kokuvelisa ubushushu obugqithisileyo.

Nangona kunjalo, xa i-RYR1 i-gene iguqula (kunye nelifa elilawulayo le-autosomal lithetha ukuba ikopi enye eguqulweyo ingaba yi-pathogenic), lo "mgcini-sango" ulahlekelwa ulawulo. Iba novakalelo olugqithisileyo kwaye ithande ukuhlala ivulekile phantsi kwezivuseleli ezithile, ibangela izixa ezikhulu ze-calcium ion ukuba zikhukulise ngokungalawulekiyo kwimicu yezihlunu.

Ngeli xesha, iiseli zemisipha ziwela kwimeko "ukuzingcaOku kudla ngokukhawuleza amandla kwaye kukhuphe ubushushu obukhulu. Ekubeni izinja zinamandla alinganiselweyo okukhupha ubushushu, xa imveliso yobushushu idlula kakhulu ukuchithwa, ubushushu bomzimba bunokwenyuka ngemizuzu (ukusuka kwi-38-39 ° C ukuya kwi-41 ° C). ukungalingani kubangela i-cascade yeengxaki: i-metabolism ye-muscle egqithisileyo ivelisa inani elikhulu le-lactic acid kunye ne-creatine kinase, eqokelela kwi-bloodstream kunye nezitho zomonakalo ezifana nezintso (i-creatine kinase inokuvala ii-tubules ze-renal) kunye nesibindi i-muscle fibers inokugqabhuka phantsi kwe-contraction eqhubekayo, ebangela i-rhabdomyolysis, i-urinary colored, intlungu kunye ne-urirycolor, ekhokelela kwi-urinary colour. Iimeko ezinzima zinokuhlakulela i-arrhythmia, i-hypotension, ukuphefumla ngokukhawuleza, kunye nokungaphumeleli kwamalungu amaninzi-ngaphandle kokungenelela ngexesha likaxakeka, izinga lokufa liphezulu kakhulu.

Apha kufuneka sigxininise ukungena okungaphelelanga: ezinye izinja zithwala iinguqu ze-RYR1 kodwa zingabonakali iimpawu kubomi bemihla ngemihla kuba ukubonakaliswa kofuzo kufuna i-trigger. Kuphela kuxa izivuseleli ezithile zenzeka apho uguqulo lusebenza kwaye iziteshi zekhalsiyam ziphuma kulawulo. Oku kuchaza ukuba kutheni abathwali abaninzi bahlala besempilweni ubomi babo bonke ukuba abazange bavezwe kwizinto ezibangelayo-kodwa banokufumana ukuqalisa ngequbuliso xa sele kuqalisiwe.

Izinto ezintathu eziphambili ezibangela i-Canine Malignant Hyperthermi

Iimpendulo zetsheyini ezichazwe ngasentla zidla ngokuvuswa ziindidi ezintathu zezinto:

1. Ii-Arhente eziKhethekileyo zokuthomalalisa (I-Primary Trigger)Esona siqhumiso sinamandla siquka amayeza athile okuthomalalisa iintlungu—njengalawohalothane, isoflurane, sevoflurane, kunye ne-depolarizing muscle relaxants njenge-succinylcholine. La machiza asebenzisana ngokuthe ngqo kunye ne-RYR1 gene eguqukileyo, iqhubekisela phambili i-calcium channels. Idatha yeklinikhi ibonisa ukuba malunga neepesenti ze-70 zeemeko ze-canine ezimbi ze-hyperthermia zenzeka ngexesha lotyando kusetyenziswa ezi zi-anesthetics, kaninzi ngaphakathi kwe-10-30 imizuzu emva kokungeniswa.Ukungena okungaphelelanga kwakhona kubonakaliswe apha: ezinye izinja ezithwala ukuguquka zingenakusabela kula machiza ngenxa yokungafani kwi-gene expression okanye umthamo we-metabolic.

2. Ubushushu beNdawo kunye noMsebenzi woMzimbaUbushushu obuphezulu kunye nokufuma kwemekobume (umzekelo, iimoto ezivaliweyo ezishushu, iibhalkhoni ezibekwe elangeni) zinciphisa ukutshatyalaliswa kobushushu. Ukuba inja yenza umsebenzi onzima phantsi kweemeko ezinjalo, ukushisa kwe-metabolic kwandisa kakhulu. Idityaniswe ne-RYR1 engaqhelekanga, oku kunokusebenzisa i-gene eguqulweyo. Iimeko ziye zaxelwa ngexesha lokuhamba ngenxa yobushushu, uxinzelelo kunye nokuhamba kancinci.

3. Ukusabela koxinzelelo olukhuluUmonzakalo wotyando, uloyiko olukhawulezileyo (umzekelo, ukuleqwa sisilwanyana esikhulu, iziqhushumbisi ezingxolayo), okanye iintlungu eziqatha (ukwaphuka, ukwenzakala) kunokubangela iadrenaline kunye nezinye iihomoni zoxinzelelo. La mahomoni asebenza ngokungangqalanga ijini ye-RYR1 eguqukileyo, ebangela ukukhutshwa kwe-calcium engaqhelekanga. I-Labrador ethwele ukuguqulwa kwakha kwavelisa i-hyperthermia eyingozi ngenxa yoxinzelelo lwengozi yemoto-umzekelo wokungena okungaphelelanga okubangelwa yi-stimuli yangaphandle.

Kubalulekile ukuqaphela ukuba ukuchaphazeleka kuyahluka kwiintlobo ezahlukeneyo.I-Labrador Retrievers, i-Golden Retrievers, i-Beagles, i-Vizslas, kunye nezinye iintlobo zinezinga eliphezulu lokuguqula i-RYR1, ngelixa iintlobo ezincinci ezifana ne-Chihuahuas kunye ne-Pomeranians zineemeko ezimbalwa ezichazwe. Ubudala budlala indima-izinja ezincinci (iminyaka eyi-1-3 ubudala) zine-metabolism esebenzayo ye-muscle, ezenza zibe sesichengeni ngakumbi kwizinto ezibangela ukuba zibe nezinja ezindala.

Uvavanyo lwemfuzo: uThintelo phambi kokuba iimpawu zivele

Kubanikazi bezilwanyana ezifuywayo, ukuqonda ezi ndlela kunye nezibangela kuvumela uthintelo olungcono:

Ukuba inja yakho yeye-auhlobo olusemngciphekweni omkhuluokanye unayo aimbali yosapho(ilifa elilawulayo lithetha ukuba izalamane zinokuthwala utshintsho olufanayo), soloko wazisa oogqirha bezilwanyana phambi kokuthomalalisa umzimba. Basenokukhetha amachiza akhuselekileyo (umzekelo, ipropofol, i-diazepam) kwaye balungiselele izixhobo zokupholisa (iipaki zomkhenkce, iingubo zokupholisa) kunye namayeza angxamisekileyo.

Ziphepheumthambo ngamandlangexesha lemozulu eshushu.

Nciphisaiimeko ezinoxinzelelo oluphezuluukunciphisa utyhileko lwe-trigger.

Ixabiso lovavanyo lwe-nucleic acidngenxa ye-canine enobungozi hyperthermia ilele ekuchongeni ukuba inja yakho iphethe utshintsho lwe-RYR1. Ngokungafaniyo novavanyo lwentsholongwane, olufumanisa usulelo, olu hlobo lovavanyo lubonisa ingozi yemfuza. Nangona inja i-asymptomatic ngenxa yokungena okungaphelelanga, ukwazi isimo sayo sofuzo kuvumela abanini ukuba balungelelanise ukunakekelwa kunye nezigqibo zonyango ukuphepha izinto ezibangela-ukugcina izilwanyana ezikhuselekileyo kule meko isongela ubomi.

Ixesha lokuposa: Nov-13-2025

Umbulali ofihlakeleyo kwi-Canine WorldMalignant Hyperthermia